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S49076 hydrochloride
CAS No. 1265966-31-1
S49076 hydrochloride( S 49076;S-49076 )
Catalog No. M11116 CAS No. 1265966-31-1
S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500mg | Get Quote | In stock |
|
| 100mg | 625 | In stock |
|
| 25mg | 217 | In stock |
|
| 5mg | 93 | In stock |
|
Biological Information
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Product NameS49076 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionS49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM.
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DescriptionS49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2; only inhibits 6% of kinases on a panel of 442 human wild-type and mutated kinases at 100 nM; inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL; causes tumor growth arrest in bevacizumab-resistant tumors in cancer xenograft models.Brain Cancer Phase 2 Clinical
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SynonymsS 49076;S-49076
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PathwayTyrosine Kinase
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TargetTAM Receptor
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RecptorAXL;FGFR1;FGFR2;FGFR3;MER;Met
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Research AreaCancer
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IndicationBrain Cancer
Chemical Information
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CAS Number1265966-31-1
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Formula Weight474.96
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Molecular FormulaC22H23ClN4O4S
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Purity>98% (HPLC)
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SolubilityDMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESC1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl
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Chemical Name3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-2,4-thiazolidinedione hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Burbridge MF, et al. Mol Cancer Ther. 2013 Sep;12(9):1749-62.
2. Clémenson C, et al. Mol Cancer Ther. 2017 Oct;16(10):2107-2119.
3. Rodon J, et al. Eur J Cancer. 2017 Aug;81:142-150.
2. Clémenson C, et al. Mol Cancer Ther. 2017 Oct;16(10):2107-2119.
3. Rodon J, et al. Eur J Cancer. 2017 Aug;81:142-150.
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