Cart
sales@molnova.com
S49076 hydrochloride
CAS No. 1265966-31-1
S49076 hydrochloride ( S 49076;S-49076 )
Catalog No. M11116 CAS No. 1265966-31-1
S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 107 | In Stock |
|
| 10MG | 170 | In Stock |
|
| 25MG | 279 | In Stock |
|
| 50MG | 442 | In Stock |
|
| 100MG | 796 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameS49076 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionS49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM.
-
DescriptionS49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2; only inhibits 6% of kinases on a panel of 442 human wild-type and mutated kinases at 100 nM; inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL; causes tumor growth arrest in bevacizumab-resistant tumors in cancer xenograft models.Brain Cancer Phase 2 Clinical
-
SynonymsS 49076;S-49076
-
PathwayTyrosine Kinase
-
TargetTAM Receptor
-
RecptorAXL;FGFR1;FGFR2;FGFR3;MER;Met
-
Research AreaCancer
-
IndicationBrain Cancer
Chemical Information
-
CAS Number1265966-31-1
-
Formula Weight474.96
-
Molecular FormulaC22H23ClN4O4S
-
Purity>98% (HPLC)
-
SolubilityDMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESC1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl
-
Chemical Name3-[[2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-2,4-thiazolidinedione hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Burbridge MF, et al. Mol Cancer Ther. 2013 Sep;12(9):1749-62.
2. Clémenson C, et al. Mol Cancer Ther. 2017 Oct;16(10):2107-2119.
3. Rodon J, et al. Eur J Cancer. 2017 Aug;81:142-150.
2. Clémenson C, et al. Mol Cancer Ther. 2017 Oct;16(10):2107-2119.
3. Rodon J, et al. Eur J Cancer. 2017 Aug;81:142-150.
molnova catalog
related products
-
Ningetinib Tosylate
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
-
S49076 hydrochloride
S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM.
-
HMN-154
HMN-154 is a novel benzenesulfonamide anticancer compound.
